Hydrazine Sulfate for Cachexia


What is cachexia?

One of the most frightening symptoms of advanced cancer is cachexia (severe, unintentional weight-loss). According to the National Cancer Institute, “It is estimated that half of all cancer patients experience cachexia, which is the rapid loss of weight accompanied by fatigue, weakness, and a loss of appetite. Cachexia is a serious problem among many patients who have advanced cancer.”

Cachexia is a vicious cycle that occurs when cancer cells consume blood glucose and produce a lactic acid by-product (acidic waste). This lactic acid is then sent to the liver to be converted back into glucose which once again goes back to feed the cancer. The more sugar, the more acid, and the cycle continues. This process is called gluconeogenesis and the process consumes enormous amounts of energy. The process may eventually cause the body to start breaking down its own tissues in order to “feed” the cancer cells. Dr. Harold Dvorak, former chief of pathology at Beth Israel Hospital in Boston, states “In a sense, nobody dies of cancer. They die of something else – pneumonia, or failure of one or more organs. Cachexia accelerates that process of infection and the build-up of metabolic poisons, this process causes death much faster than the tumor would.”

Dr Joseph Gold and his work to stop cachexia

Dr Joseph Gold

Dr Joseph Gold


Dr. Joseph Gold was a research scientist for NASA, a United States Air Force officer, and a medical doctor. After completing his distinguished military career, he embarked on a mission with one goal in mind, to answer the question: “Is there a chemical way to inhibit gluconeogenesis and stop cachexia?” In 1969, Dr. Gold heard a speech by biochemist Paul Ray explaining that hydrazine sulfate could shut down the enzyme that is necessary for the production of glucose from the lactic acid by-products. He immediately tested hydrazine sulfate on mice and found that it did indeed  inhibits gluconeogenesis, thus reversing the deadly cachexia cycle.  Hydrazine sulfate is not recommended as a primary cancer treatment, but it can stop the deadly cycle of cachexia and wasting which can cause premature death to the patient.

How to obtain Hydrazine Sulfate

Joseph Gold, M.D., is the director of the Syracuse Cancer Research Institute and the developer of hydrazine sulfate as an anticancer drug.  Read his own report in the link below for more information on this therapy. Also, only a doctor can contact the clinic to obtain hydrazine sulfate for a patient.

Dietary restrictions when taking hydrazine sulfate

Hydrazine Sulfate is an MAOI (Momoamine Oxidase Inhibitor). What that means is that it will inhibit an enzyme that breaks down monoamines (serotonin, norepinephrine, and dopamine). These are the chemicals in the brain that make us happy. MAO inhibitors are often prescribed as antidepressants. However, MAOs have another job in the body: they metabolize tyramine, which is an amino acid. When taking an MAO inhibitor such as hydrazine sulfate, tyramine is not broken down, so eating foods that contain tyramine can raise your blood pressure and heart beat dramatically and cause severe headaches.  This can be a very dangerous condition, especially for someone battling cancer. Most of the foods containing tayramine are not on the cancer diet plan anyways so you should be avoiding them to begin with, but they are listed belowFoods containing tyramine are mainly aged, fermented, or pickled foods, such as most cheeses (except cottage cheese, cream cheese, and fresh Mozzarella), as well as lunch meats, hot dogs, yogurt, wines and beers.

Here is a partial list of foods that contain tyramine, however it is not a complete list so caution should be taken.  If a headache should arise, a food containing tyramine may have been ingested and you should eliminate those foods from your diet.

  • Barley grass, and all barley supplements,
  • Dry and fermented sausage (bologna, salami, pepperoni, corned beef,
  • pickled herring and salted dried fish,
  • beef or chicken liver,
  • broad beans and pods (lima, fava beans, lentils, snow peas, and soy beans),
  • meat extracts, meat tenderizer, MSG (Accent),
  • bouillon
  • yeast extracts/brewer’s yeast,
  • beer and ale, red wine (chianti, burgundy, sherry, vermouth),
  • sauerkraut,
  • pickles,
  • fruits such as oranges, tangerines, lemon, grapefruit, bananas, avocados,
  • figs and dates,
  • dried fruits such as raisins,
  • red plums, raspberries, pineapples,
  • any overripe fruits
  • cultured dairy products (buttermilk, yogurt, and sour cream),
  • chocolate,
  • caffeinated beverages (coffee, tea, and cola drinks),
  • white wine, port wines, distilled spirits,
  • soy sauce,
  • miso,
  • tofu and tempeh,
  • peanuts, almonds,
  • pumpkin seeds.
  • In general, any high protein food that has undergone aging should be avoided.
  • over-the-counter cold or allergy remedy should also be avoided.” 
  • http://www.mnwelldir.org/docs/cancer1/altthrpy2.htm

Contraindications–  “Hydrazine sulphate is a monoamine oxidase inhibitor and the following should not be used during this therapy:

  • barbiturates and tranquilizers (e.g. Thorazine, Compazine, Xanax, Valium, Dalmane, Ativan, Restoril, Halcion, Nembutal and Seconal, to name but a few)
  • tranquilizers or sedatives in doses greater than 100 mg per day, this is especially true for benzodiazephines and phenothiazines which should be avoided.
  • agents which suppress the central nervous system such as morphine.
  • antihistamines
  • ethanol
  • alcoholic beverages
  • antiemetics that are used to treat nausea and vomiting
  • foods with tyramine that are listed above.
  • Vitamin B6
  • vitamin c in doses above 250 mg (from all sources)
  • Hydrazine sulphate should be taken in exact doses. Overdosing can do more harm than good.

Additional Resources-

The Truth About Hydrazine Sulfate by Dr Joseph Gold

Syracuse Cancer Research Institute- Contact information

Cancer Tutor on Hydrazine Sulfate, please read for complete information, protocol and vendor for HS


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