Hydrazine Sulfate for Cachexia

What is cachexia?

One of the most frightening symptoms of advanced cancer is cachexia, a severe, unintentional weight-loss. According to the National Cancer Institute, “It is estimated that half of all cancer patients experience cachexia, which is the rapid loss of weight accompanied by fatigue, weakness, and a loss of appetite. Cachexia is a serious problem among many patients who have advanced cancer.”

Cachexia is a vicious cycle that occurs when cancer cells consume blood glucose and produce a lactic acid by-product (acidic waste). This lactic acid is then sent to the liver to be converted back into glucose which once again goes back to feed the cancer. More glucose creates more acid…. and the deadly cycle continues. This is called gluconeogenesis and it consumes enormous amounts of energy. This process may eventually cause the body to start breaking down its own tissues in order to “feed” the cancer cells. Dr. Harold Dvorak, a former chief of pathology at Beth Israel Hospital in Boston, states “In a sense, nobody dies of cancer. They die of something else – pneumonia, or failure of one or more organs. Cachexia accelerates that process of infection and the build-up of metabolic poisons, this process causes death much faster than the tumor would.”

Dr Joseph Gold promotes the use of hydrazine sulfate to stop cachexia

Dr Joseph Gold

Dr Joseph Gold

Dr. Joseph Gold worked as a research scientist for NASA, was a United States Air Force officer as well as a medical doctor. After completing his distinguished military career, he embarked on a mission with one goal in mind~ to answer the question: ‘Is there a chemical way to inhibit gluconeogenesis and stop cachexia?’ In 1969, Dr. Gold listened to a speech given by biochemist Paul Ray explaining that hydrazine sulfate could shut down the enzyme that is necessary for the production of glucose from the lactic acid by-products. He immediately tested hydrazine sulfate on mice and found that it did indeed inhibit gluconeogenesis, thus reversing the deadly cachexia cycle.

Hydrazine sulfate is not recommended as a primary cancer treatment, but it can stop the deadly cycle of cachexia and wasting which can cause premature death to the patient.

How to obtain Hydrazine Sulfate

Joseph Gold, M.D., is the director of the Syracuse Cancer Research Institute which is a supplier of hydrazine sulfate.  You can read his report in the link below for more information on this protocol. It is important to note that only a doctor can obtain hydrazine sulfate from the institute, but Cancertutor.com does suggest this online vendor for those wishing to obtain it online.

Dietary restrictions when taking hydrazine sulfate

Hydrazine Sulfate is an MAOI (Momoamine Oxidase Inhibitor). What that means that it will inhibit an enzyme that breaks down monoamines (serotonin, norepinephrine, and dopamine). These are the chemicals in the brain that make us feel good, and that is why MAO inhibitors are often prescribed as antidepressants. MAOs have another job in the body as they are responsible for metabolizing the amino acid tyramine.

When taking a MAO inhibitor such as hydrazine sulfate, tyramine will not be broken down, so eating foods that contain tyramine can raise your blood pressure and heart beat dramatically and cause severe headaches.  This can be a very dangerous, especially for someone who is battling cancer. Most of the foods containing tayramine are not on the anticancer diet plan anyways but they are listed below for your convenience There is a partial list of foods that contain tyramine below, however it is not a complete list so caution should be taken.  If you experience a headache while on Hydrazine Sulfate it may be because you ingested a food that contains tyramine and you should eliminate those foods from your diet while taking HS.

  • barley grass, and all barley supplements,
  • dried and fermented sausage (bologna, salami, pepperoni, corned beef,
  • lunch-meats, hot dogs
  • meat extracts, meat tenderizer, MSG (Accent),
  • pickled herring and salted dried fish,
  • beef or chicken liver,
  • broad beans and pods (lima, fava beans, lentils, snow peas, and soy beans),
  • bouillon
  • yeast extracts/brewer’s yeast,
  • beer and ale, red wine (chianti, burgundy, sherry, vermouth),
  • distilled spirits,
  • sauerkraut,
  • pickles,
  • fruits such as oranges, tangerines, lemon, grapefruit, bananas, avocados,
  • figs, dates, raisins,
  • red plums, raspberries, pineapples, any overripe fruits
  • cultured dairy products (buttermilk, yogurt, and sour cream),
  • cheese (except cottage cheese, cream cheese, and fresh Mozzarella)
  • chocolate,
  • caffeinated beverages (coffee, tea, and cola drinks),
  • soy sauce, miso,
  • tofu and tempeh,
  • peanuts, almonds,
  • pumpkin seeds.

Contraindications–  “Hydrazine sulphate is a monoamine oxidase inhibitor and the following should not be used during this therapy:

  • barbiturates and tranquilizers (e.g. Thorazine, Compazine, Xanax, Valium, Dalmane, Ativan, Restoril, Halcion, Nembutal and Seconal, to name but a few)
  • tranquilizers or sedatives in doses greater than 100 mg per day, this is especially true for benzodiazephines and phenothiazines which should be avoided.
  • morphine or other agents that suppress the central nervous system.
  • antihistamines
  • ethanol
  • alcoholic beverages
  • medications to treat nausea and vomiting
  • foods with tyramine that are listed above.
  • vitamin B6
  • vitamin c in doses above 250 mg (from all sources)
  • Hydrazine sulphate should be taken in exact doses.

Additional Resources-

Cancer Tutor on Hydrazine Sulfate, please read for complete information, protocol and vendor for HS

Read more ways to stop the cycle of cachexia

Online vendor of hydrazine sulfate

  Nutricost D-Ribose

Cancer: Step Outside the Box

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Cancer is a wake up call which needs to be addressed on multiple fronts.  It is the result of an overly toxic body with an overwhelmed and collapsed immune system due to eating nutritionally depleted diets, exposure to toxins, and having poor lifestyle habits. Research an anticancer diet, adding supplements, detoxing the body, and making lifestyle changes so you can address a cancerous situation with a multifaceted approach.


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