Graviola (soursop)- The tree itself is a small evergreen that naturally grows in the tropical rainforests of South America. The large green fruit has a dull spiked surface which can be removed by tearing off the skin revealing the soft, creamy fruit embedded with numerous black seeds. The pulp, seeds, roots, leaves and bark all offer health benefits and have been used over the centuries by medicine men and native Indians to treat various illnesses.
In 1976, the National Cancer Institute funded a study at Purdue University on the soursop fruit which demonstrated its amazing cancer-fighting potential. Results of this research showed that graviola was quite effective at attacking and destroying malignant cells. Soursop contains a unique set of chemicals called “annonaceous acetogenins” that are produced in the bark, leaves, and seeds which display anti-tumor properties that are selectively toxic against various types of cancer cells (including colon cancer cells), yet are harmless to regular healthy cells. These acetogenins have also been documented to be anti-parasitic and anti-microbial as well. Three separate studies have shown that these acetogenins are superb inhibitors of enzyme processes only found in the membranes of cancerous tumor cells. Graviola can be found in tea, tincture and supplement form.
Here is a quote from Purdue University’s research on Graviola: “In 1997, Purdue University published information with promising news that several of the Annonaceous acetogenins ‘not only are effective in killing tumors that have proven resistant to anticancer agents, but also seem to have a special affinity for such resistant cells.’ In several interviews after this information was published, Purdue pharmacologist Dr. Jerry McLaughlin, the lead researcher in most of Purdue’s studies on the Annona chemicals [Graviola], says cancer cells that survive chemotherapy may develop resistance to the agent originally used against them as well as to other, even unrelated, drugs. ‘The term multi-drug resistance (MDR) has been applied to this phenomenon,’ McLaughlin says. He explains that such resistance develops in a small percentage of cancer cells when they develop a ‘Pglycoprotein mediated pump’ capable of pushing anti-cancer agents out of the cell before they can kill it. Normal cells seldom develop such a pump.‘If having this pump was such a good deal, all cells would have it. But all cells don’t,’ McLaughlin says in a statement from Purdue. ‘In a given population of cancer cells in a person, maybe only 2% of the cancer cells possess this pump. But it’s those 2% of cancer cells that eventually grow and expand to create drug resistant tumors.’ McLaughlin and his colleagues say some studies have tried to bypass these pumps by keeping them busy with massive doses of other drugs, like the blood pressure agent verapamil. In this way, it was hoped that some of the anti-cancer drugs would enter the cell and destroy it. But this only caused potentially fatal side effects such as loss of blood pressure. In the June  issue of Cancer Letters, the Purdue researchers reported that Annonaceous acetogenin, bullatacin, [Graviola] preferentially killed multi-drug resistant cancer cells because it blocked production of adenosine triphosphate, ATP – the chief energy-carrying compound in the body. ‘A multi-drug resistant cell requires a tremendous amount of energy to run the pump and extrude things out of the cell,’ McLaughlin says. ‘By inhibiting ATP production, we’re essentially pulling the plug on its energy source.’ But what about the effect on ATP of normal cells? ‘Normal cells and standard cancer cells may be able to minimize the effect of this compound because they don’t require vast amounts of energy needed by the pump-running cells,’ the Purdue researcher says. ‘The resistant cell is using its extra energy for this pump as well as to grow, so it is really taxed for energy. When we mess with the energy supply, it kills the cell.’”
Make a tea- You can make a soursop tea using either fresh or dried leaves by steeping the leaves in boiling water. Benefits include alleviating migraine headaches, diarrhea, cough, back pain, stress, high blood pressure, and nerve ailments. If you suffer from insomnia try drinking this tea before bedtime.
Precautions- There have been concerns that regular ingestion of the graviola fruit and supplements by residents of Guadeloupe and other Caribbean countries may lead to atypical Parkinsonian-type symptoms. Until this is clarified further, it is a good idea to take frequent breaks from the use of the supplements. One such method would be to take one capsule per day for 5 days out of 7 every week, and then stopping the treatment for the last week of every month, and then stopping the treatment again for one whole month after taking it for 3 consecutive months, following the same manner as noted above.
Contraindications- people with Parkinson’s Disease should not take graviola unless it is an alkaloid-free preparation. There is also a possibility of allergic reactions in sensitive individuals. Pregnant women should not take graviola. Also graviola should not be used with any other alternative cancer treatments. Some of those include Vitamin C, Enzyme Therapy, electromedicine (e.g. GB-4000), MSM, DMSO, Hydrogen Peroxide therapy, Limu Juice Protocol, Budwig protocol, and protocols that consist of maple syrup or honey, as all may interfere with graviola.
How to juice the soursop fruit.
Paw Paw trees are native to North America, and can be found growing in hardiness zones 5-8. The tree also produces an edible fruit that weighs about 5 to 16 ounces, measuring 3 to 6 inches in length. The fruit usually has 10 to 14 brownish/blackish seeds, and often grows in clusters of up to nine fruits which are soft and thin skinned. The fruit starts out green but matures to yellow or brown, and has a flavor somewhat similar to both bananas and mangoes, and has more protein than most fruits.
The fruit of the Paw Paw is high in vitamins, minerals, antioxidants, fiber and other beneficial compounds, but it is the twigs that contain the highest anti-cancer compounds. As an added bonus, Paw Paw has anti-parasitic qualities when taken internally, and shampoos which contain the active ingredient can be used as an effective, non-toxic treatment for head lice.
The difference between graviola and paw paw for cancer- In the 1970’s, the National Cancer Institute started funding the research of Dr. Jerry McLaughlin at Purdue University in order to find botanical substances that have anti-cancer potential. He tested and screened over 3500 species of plants, and found that the acetogenin compounds of the Annonaceae family had the most potential. He, along with 13 of his Ph.D. students and others, worked with the various species which included paw paw and graviola. They found and isolated over 400 acetogenins in this family, and used some very sophisticated chemical modeling techniques to determine and show the differences. They found about 50 acetogenins in the paw paw, and about 30 in the graviola. Of more importance than the number of acetogenins found in each plant was the potency of these compounds. Dr. McLaughlin and his students did chemical structure analysis on many of these compounds, and without exception found that those acetogenins with a “double ring” chemical structure were many, many times more powerful than those with only single ring structures. Graviola has the single ring compounds, while the Paw Paw’s acetogenins have several double ring compounds (e.g. bullatacin) which makes Paw Paw much more powerful.
Cancer cells and energy production -cancer cells create their energy through a process involving the fermentation of glucose. The energy produced is called adenosine tryphosphate, or ATP for short. Some studies indicate that they need anywhere from 10-17 times as much ATP than normal cells do in order to survive and multiply. So if the ATP that is produced by the mitochondria can somehow be controlled or reduced significantly, those cells can be negatively impacted, hopefully making them die off.
Paw Paw works by slowing down or stopping the production of ATP, therefore lowering the voltage of the cell. For normal cells, there is plenty of ATP, so lowering the levels of ATP will have no effect on them. However because cancer cells create energy through fermentation, ATP is far more critical for their survival. Pawpaw gravitates towards the cells that use high amounts of energy and then cuts off this energy supply. Since cancer cells use 10-17 times as much energy as a normal cell, Paw paw will be naturally drawn to these cancer cells.
When the ATP level, and the energy of the cell level drops to a critical level they will begin to fall apart. The residual pieces of the dead cancer cell are called lysing and are cleaned up by other cells called phagocytosed. In some circumstances, when cancer cells are clustered together, a large amount of lysing can build up in the system. This can be especially dangerous for lung cancer and brain cancer patients where a clustered amount of lysing can be life threatening.
Paw Paw has been shown to kill multiple-drug resistant cells which are created as a result of taking chemotherapeutic agents. This is especially important information for a patient who has received orthodox treatments and is experiencing a recurrence of disease, as a high percentage of their cancer cells are going to be multiple-drug resistant cells.
Precautions and Contraindications for Paw Paw- If no cancer, parasitic infection, or other high energy users are available, Paw Paw may gravitate towards fast growing cells including a developing fetus or the lining of the digestive and intestinal system. Therefore, pregnant women and those without cancer should not take paw paw. Patients with Parkinsons Disease should not take Paw Paw unless alkaloid-free preparations are used. Those with lung or brain cancer should not take Paw Paw due to the concern of lysing buildup. There is also a possibility of allergic reactions in sensitive individuals. Some people with cancer have reported digestion distress such as nausea. For this reason it is recommended to take Paw Paw with food. Paw Paw should not be used with any other alternative cancer treatments. Some of the protocols that may interfere with paw paw include electromedicine, MSM, DMSO, Vitamin C, Limu Juice protocol, Hydrogen Peroxide, Budwig protocol and protocols with maple syrup or honey.
Dr. Jerry McLaughlin presents a lecture on his life’s work- finding things in plants that fight cancer.
Eating the Paw Paw fruit