The benefits of Grape Seed Extract
Grape seed extract is made from the crushed seeds of red wine grapes and can be beneficial for treating a number of health conditions including: poor circulation, high cholesterol, diabetes-related eye disease, age related vision loss, and to treat swelling that is associated with injury. Full of antioxidants, grape seed extract can also help to protect the cells from free radical damage, and it has the ability to selectively target many types of cancerous cells.
Studies with grape seed extract for cancer
In 2009, research from The City of Hope Center in California concluded that grape seed extract could reduce VEGF levels. VEGF is a protein that produces new blood vessels and this is an essential component for tumor growth. Shiuan Chen, Professor of tumor biology, demonstrated that the grape seed extract blocks the formation of a protein HIF-1, which is produced in situations of low blood oxygen and causes more VEGF to be produced and more blood vessels to form. Bone cancer, brain tumors, bladder cancer, bile duct and colorectal cancers were all named as potential targets by the researchers. This also confirmed a previous study from 2006 (Free Radical Biology and Medicine, Feb 2006) that grape seed extract could prevent the growth of vascular epithelial growth factors in glioblastoma and other cancers. Link to the study.
Dosage suggestions for Grape Seed Extract:
According to Drugs.com, a standard dose of grape seed consists of 50 milligrams to 300 milligrams daily. It has also been reported that doses of 900 milligrams were used in some of the studies with grape seed extract.
The University of Maryland Medical Center notes the following dosage suggestions: 25 to 150 milligrams daily for general antioxidant support, 150 to 300 milligrams daily for chronic heart or blood vessel issues, and 200-600 milligrams taken for edema or swelling, and up to 900 milligrams for more serious issues.
If you are supplementing with the larger doses they should be divided and taken throughout the day.
To derive the most benefit from this supplement it must be taken on a consistent basis.
Grape seed can interact with some medications, including blood-thinners such as warfarin (Coumadin).